The opera was first performed at the Teatro San Carlo in Naples on 4 November 1767, the nameday of King Charles III of Spain, the former ruler of the Kingdom of Naples whose birthday and nameday were still celebrated with operatic productions under the rule of his son Ferdinand.
18th-century Italian operas in the serious style are almost always set in a distant or legendary past and are built around historical, pseudo-historical, or mythological characters.
The main character of Lucchini's Farnace is based on the life of King Pharnaces II of Pontus, whose conflicts with the Roman Republic eventually led to his death.
In order to avoid seeing his entire family falling into the hands of the enemy, Farnace commands his wife Tamiri to kill their son and then herself, although this never happens.
Selinda, Farnace's sister, is taken captive by the Roman Atridate, who falls in love with her, as does the army captain Gilades.