The Farnum Block was an historic commercial building located at 1 South Main Street, in Uxbridge, Massachusetts.

[2] The Farnum Block stood at the northern end of a short series of commercial blocks in the center of Uxbridge, on the west side of Main Street at its junction with Mendon Street.

It was three stories in height, built of red brick in the Renaissance Revival style.

The ground floor housed two commercial store fronts, topped by a metal cornice.

The upper floors were divided vertically into three sections, defined by recessed arched panels, with paired sash windows at each level.