Khan was born and raised in Bolton, Greater Manchester, to a Pakistani Punjabi Rajput family with roots in Matore village of Kahuta Tehsil, located in Rawalpindi District of Punjab, Pakistan.

[15] He is the first cousin of English cricketer Sajid Mahmood, related through a paternal grandfather, Lal Khan Janjua, who moved to England after being discharged from the Pakistan Army.

[28] Dean Powell, who has trained former world champions Duke McKenzie and Lloyd Honeyghan, worked with Khan until a decision on a permanent trainer was made.

In the first round, Prescott came out fast and landed good shots; a stiff jab jerked Khan's head back and foreshadowed what was to come.

"[44][45] On 6 October 2009, Frank Warren confirmed that Khan would defend his WBA light-welterweight title against undefeated Dmitry Salita (30–0–1, 16 KOs), the mandatory challenger, on 5 December, at the Metro Radio Arena in Newcastle upon Tyne, England.

[55] Maidana (29–1, 27 KOs), after failing to challenge undefeated WBO light-welterweight champion Timothy Bradley, postponed the fight to 19 June due to a back injury.

Khan had some trouble with the awkward and resilient southpaw, who was difficult to hit cleanly, but he was both too quick and too busy for McCloskey, winning all six rounds on all three cards.

[70] On 31 May 2011, Khan agreed to fight 33-year-old two-weight champion Zab Judah (41–6, 28 KOs) in attempt to unify the WBA, and IBF light-welterweight titles in Las Vegas on 23 July.

[84] Khan appealed the decision to the sanctioning bodies, citing the poor refereeing, and the presence of a "mystery man" at ringside who could have interfered with the scoring.

[102] Following his victory over Molina, Khan returned to the UK for a fight against 33 year old Julio Díaz (40–7–1, 29 KOs) on 27 April 2013 in a 143 lbs catch-weight bout.

[118] After Khan himself initially announced the fight on his wife's YouTube channel on 3 April, a welterweight bout against former WBO light-welterweight champion Chris Algieri (20–1, 8 KOs) was later finalised to take to place on 29 May 2015, at the Barclays Center in Brooklyn, New York.

This made it one of the biggest recent PPV fights, behind Miguel Cotto vs. Canelo Álvarez, and surpassing Manny Pacquiao vs. Timothy Bradley III and Floyd Mayweather Jr. vs. Andre Berto.

[134] On 26 February 2017, Khan and reigning WBO welterweight champion Manny Pacquiao both tweeted a deal had been reached between both camps for a 'super fight' worth potentially £30 million to take place on 23 April in the United Arab Emirates.

[136][137][138] Speaking to Bob Arum on 1 March, Pacquiao's adviser Michael Koncz confirmed the fight would place on 20 May in the United Arab Emirates.

The deal meant Khan would fight exclusively on Sky Sports, with his return bout in the UK taking place on 21 April at the Echo Arena in Liverpool.

[144] At the official press conference, a brawl broke out after Lo Greco made comments about Khan's personal life, "After the Canelo loss you went on a losing streak – family, wife and then you go out and tweet to the heavyweight champion of the world.

"[151] During the post-fight press conference, Khan named a number of top welterweights including Keith Thurman and Errol Spence, but stated he would like to bring Adrien Broner over to the UK for a big fight.

[152] At an official press conference on 28 June, it was announced that Khan would return to Arena Birmingham for the first time since 2008, against Colombian Samuel Vargas (29–3–2, 14 KOs), who has been a five-fight unbeaten run since November 2016.

[161] Hearn announced that the fight set a viewership record, for the biggest live audience on UK subscription television in boxing history.

[162] On 9 December 2018, it was reported that Top Rank had offered Khan a guaranteed $5 million purse, plus a percentage of PPV revenue, to fight Terence Crawford on 23 March 2019 at Madison Square Garden in New York.

In round six, Khan was hit by an accidental low blow, and during the allocated five-minute recovery time, trainer Virgil Hunter threw in the towel to hand Crawford a TKO victory.

[172] On 12 July 2019 in Jeddah, Saudi Arabia, Khan defeated former IBF featherweight champion Billy Dib by technical knockout in the fourth round to win the vacant WBC International welterweight title.

[177] In March 2021 Khan officially announced his first-ever signing, Tal Singh and is now managing the former England amateur champion, who he is hoping to guide towards a historic world title triumph.

[179] Based in Islamabad, the Amir Khan Academy is planning to train Pakistani amateur boxers competing at the 2018 Asian Games in Indonesia.

[182] SFL has had several Bollywood stars, including Sanjay Dutt, Ajay Devgn, Tiger Shroff, and Jacqueline Fernandez, as promoters and team ambassadors.

SBL has had several Bollywood stars joining as team ambassadors, including Suniel Shetty, Rana Daggubati, Sushant Singh Rajput, Randeep Hooda, and Sohail Khan.

The couple then flew back to Khan's hometown of Bolton where a second celebration, a traditional Walima, took place in Manchester, which included 4,000 guests.

After the 2004 Indian Ocean tsunami, he was among those who raised money for its victims,[201] and in the following year he visited Pakistan to dispense food in a camp set up after the Kashmir earthquake.

[202] He has also been involved with a campaign that promotes child safety around British railways,[203] one that seeks improvements to the criminal justice system,[204] and another that encourages men to play a role in ending violence against women.

[206] In December 2013, Khan hosted a fundraising dinner to support Islamic Relief's Philippines Appeal in the wake of Typhoon Haiyan, raising £83,400.