[3] The college was founded in 1951 by Jerome M. Fernandez Thuppasseril, the first native Bishop of Quilon.

The college was formally inaugurated on 29 December 1952 by Norman Cardinal Gilroy, Papal Legate to India.

It was elevated to the status of a first grade college with the introduction of degree courses in Commerce, Economics and Zoology.

Physical resources were added in the form of hostels, sports pavilions, chemistry block, auditorium, playgrounds, an NCC office, a hockey stadium, a language lab, basketball courts, a botany garden, computer labs and research centres.

Notable alumni include: Masterpiece (2017 film) shooting took place in Fatima Mata National College, Kollam