She was based in the town of Abéché, located approximately 80 kilometres west of the border with the Sudan's conflict-torn Darfur region.

In 2007, Chad was hosting over 280,000 refugees and over 170,000 internally displaced persons, most in the eastern region,[6] and she was tasked with working for their return.

[7] The official's functions consist in providing support and guidance to a team composed of seven United Nations agencies and over 40 international non-governmental organizations (NGOs) working in eastern Chad.

She was to succeed the disgraced Jerome Valcke, who had been banned from activities relating to football for 12 years,[8][9] and replaced acting Markus Kattner, who was also implicated in corruption.

[4] On 20 June 2016 she assumed the role of FIFA secretary general,[12] responsible for overseeing the commercial and operational side of the organisation.

[17][4] In July 2023, Samoura travelled to Australia in NAIDOC Week, ahead of the 2023 FIFA Women's World Cup, learning about the culture of Australian First Nations people in the Top End and attending a football clinic in Darwin, Northern Territory.

[19] When Samoura visited the AU Pavilion at the Expo 2020 in Dubai in 2021 with other FIFA Officials, the AU Expo Commissioner General, Levi Uche Madueke, said of Samoura, "She is a living testimony of the great human spirit that women across the African continent have, and her astute leadership should serve as a model worth replicating as we build towards the Africa we want, which involves the development of capable and credible leaders, especially amongst our women and youth".