She was first married in 1516 to Mustafa Pasha, governor of Antakya; however they divorced when it turned out that he was homosexual and had no interest in her.
She complains that her husband's open display of homosexual tendencies deeply offends her, saying, "My royal padishah, I have not smiled for one day, for one hour since my coming here one year ago...
[1][2] Then, she married in 1522 to Kara Ahmed Pasha, who was the Grand Vizier of the Ottoman Empire between 1553 and 1555, and maybe they had two daughters.
After his execution, she went to live in Bursa or, according to other sources, was forcibly married in 1562 to Hadim Ibrahim Pasha, presumably as a punishment for her intrigues.
In the TV series Muhteşem Yüzyıl, Fatma Sultan is played by Turkish actress Meltem Cumbul.