Fayette Courthouse Square Historic District is a national historic district located at Fayette, Howard County, Missouri.

It developed between about 1828 and 1947 and includes representative examples of Second Empire, Italianate, and Romanesque Revival style architecture.

Located in the district is the separately listed Dr. Uriel S. Wright Office.

Other notable buildings include the Fayette Public Library (1914), City Hall (1925), New Opera House Block (1903), A. F. Davis Bank (c. 1885), Commercial Bank (1910), The New Century Block Building (1902), Bell Block Building (1883), U.S. Post Office Building (1925), Howard County Jail and Residence (c. 1889-1894), and Howard County Courthouse (1887).

This article about a property in Howard County, Missouri on the National Register of Historic Places is a stub.