The Fayette National Bank Building, also known as the First National Bank Building or 21C Museum Hotel Lexington, is a historic 15-story high-rise in Lexington, Kentucky.

The building was designed by the prominent architecture firm McKim, Mead & White and built by the George A. Fuller Company from 1913 to 1914.

It was added to the National Register of Historic Places on February 27, 1980.

The building was reconfigured into 88 hotel rooms, a restaurant and museum space.

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