It is headed by a Minister appointed by the President, assisted by a Permanent Secretary, who is a career civil servant.

President Bola Tinubu, GCFR on 16 August 2023 appointed Uche Nnaji as the Minister of Science and Technology.

Mr James Sule, mni is the current permanent secretary in the ministry.

[2] The ministry engages in the following activities:[1] The Computers for All Nigerians Initiative (CANI) program is focused on enhancing Nigeria's economic and social foundation by supplying access to personal computers (PCs) and internet to its citizens.

[3] Legal, Press, Internal Audit and Private Public partnership (PPP).