It was founded on January 17, 1909 as the Free University School of Manáos, born of the same late-19th century economic boom that gave Manaus its rubber barons.

The economic downturn that followed the collapse of the rubber market, as well as the logistical problems of being located in the Amazon Rainforest, led the school to curtail its academic offerings down to just a law program.

On June 12, 1962, Brazilian federal law 4.069-A under the authorship of Senator Arthur Virgílio Jr. reinvigorated the school as the state-owned University of Amazonas.

The following is a list of the campuses and their respective courses offered: Located in Benjamin Constant, city of Alto Solimões.

The Multicampi of Humaitá offers the following undergraduate courses: Degree in Agronomy, Biology, Chemistry, Mathematics, Physics, Environmental Engineering, Letters - English Language and Literature, Letters - Portuguese Language and Literature and Pedagogy.