Federico Mussini made his debut for Grissin Bon Reggio Emilia in May 2013 against Pallacanestro Virtus Roma, but only played one minute.
[2][3] Mussini was loaned to Stella Azzurra Roma for the 2013-14 Nike International Junior Tournament, where he was named to the All-Tournament team after averaging 19.2 points, 3.2 rebounds, 1.8 assists, and 2.5 steals.
[4] In the 2014-15 season, Mussini saw increased role for Reggio Emilia as a back-up point guard to Andrea Cinciarini.
[8] On June 6, 2017, Mussini officially left St. John's to return in Italy and signed a three-year deal with Pallacanestro Reggiana.
[17] Mussini was a member of the 2014 Italian Under-18 team that played in the Albert Schweitzer Tournament, where he led Italy to first place over USA.