In 2017, at the age of 35, López won the Aegon Championship at The Queen's Club, London, beating Marin Čilić in a third set tiebreak.

Unlike most Spanish players, who almost always prefer clay courts due to the popularity of that surface in their country, López is an exceptionally strong grass-court player, with three quarter-final runs at Wimbledon (his strongest Grand Slam showing), as well as 4 titles on grass at the Eastbourne International in 2013 and 2014 and at the Queen's Club Championships in 2017 and 2019.

This is due in part to his more traditional playing style, which is more like grass-court legends Pete Sampras and Roger Federer than fellow Spaniards Rafael Nadal and Tommy Robredo.

After early losses in Cincinnati, Long Island, the US Open, and Moscow, he reached the quarter-finals of Vienna, the Madrid Masters, and Basel.

In 2004, López began the year with a 1–3 record, losing in the first rounds of Sydney, the 2004 Australian Open, and Milan, with his only win coming at the Davis Cup.

In 2008 López once again had a bad start, but rebounded at the 2008 Dubai Tennis Championships by reaching the finals, losing to Andy Roddick.

He also helped the Spanish Davis Cup team to win the title against Argentina by beating Juan Martín del Potro.

In the midst of his bad run, he won a title at the Open Castilla y León Challenger event, beating Adrian Mannarino in straight sets.

López started his 2010 season by playing in the 2010 Medibank International Sydney, where he lost to eventual runner-up Richard Gasquet in the first round.

He then competed in the 2010 Australian Open, where he reached the third round, defeating Pablo Cuevas and Rainer Schüttler, but lost to seventh seed Andy Roddick in a close four-setter.

He then reached the third round of the 2010 BNP Paribas Open, losing to sixth seed Robin Söderling, after defeating Paul-Henri Mathieu and receiving a bye.

He then won his first clay victory of the season by reaching the third round of the 2010 Barcelona Open Banco Sabadell, losing to Robin Söderling.

At the 2010 Internazionali BNL d'Italia, López reached the quarter-finals, losing to Ernests Gulbis, but upset Marin Čilić en route.

He then lost three straight matches, beginning in the semi-finals of the 2010 Farmers Classic to Andy Murray, and the first rounds of the 2010 Rogers Cup and the 2010 Western & Southern Financial Group Masters.

Feliciano made it to the quarter-finals of the 2011 Suisse Open by defeating Michael Lammer and Daniel Gimeno Traver in the first two rounds.

He recorded a big win over fellow countryman and former world number one Juan Carlos Ferrero in the first round of the 2011 Western & Southern Open.

At the 2012 Olympics, he beat Russian Dmitry Tursunov and Argentine Juan Mónaco, but was defeated by Frenchman Jo-Wilfried Tsonga in straight sets with one tie-breaker.

At the US Open, he beat Robin Haase and compatriot Pablo Andújar, but could not stand up to eventual champion Andy Murray in the third round, against whom he lost in four sets with three tie-breakers.

The week before Wimbledon, López won his first grass-court title by beating Gilles Simon in three sets in the final of the Aegon International in Eastbourne.

However, one week later, López successfully defended his Aegon International title, defeating Richard Gasquet for the first time in six attempts, 7–5 in the deciding set.

The Spaniard claimed wins over Rafael Nadal, John Isner, and Mikhail Youzhny at the 2014 Shanghai Masters, then lost the semi-final match to Gilles Simon.

In 2016 Lopez achieved one of the greatest highlights of his career by winning the French Open doubles championship along with compatriot Marc López.

Alongside his partner Marc López, they defeated the Bryan brothers (Bob and Mike) in the quarter-finals of the men's doubles tournament, the score 7–6(7–2), 4–6, 6–3.

[10] The pair eventually lost in the semi-finals against fellow countrymen Pablo Carreño Busta and Guillermo García López in straight sets.

López started the year representing Spain in the Hopman Cup, along with Lara Arruabarrena, but didn't make it past the round robin.

This culminated with losses to Thomas Fabbiano in the Monte Carlo qualifying rounds, Fernando Verdasco in Barcelona, Damir Džumhur in Geneva, and Ivo Karlović at Roland Garros.

He lost in the first round at the 2021 Wimbledon Championships to 26th seed Daniel Evans but attained also a new record when he appeared in his 77th consecutive Grand Slam.

[23] With his participation in the 2022 Wimbledon Championships he made his 81st main draw Grand Slam appearance, equaling Roger Federer's record.

[28] After receiving a main draw wildcard for the Mexican Open in Acapulco, in the first round Lopez defeated Christopher Eubanks in straight sets and scored his 504th singles career win.

[37][38] López has appeared as a model for the likes of Hugo Boss and Elle,[39][40] and endorses Braun shavers and L'Oréal products.