Ferdinand, Duke of Calabria (Spanish: Fernando de Aragón, Duque de Calabria) (15 December 1488 – 20 October 1550) was a Neapolitan prince who played a significant role in the Mediterranean politics of the Crown of Aragon in the early 16th century.
Born in Andria, Apulia as son of the future King Frederick and his second wife, Isabella del Balzo.
An alliance of Louis XII of France and Ferdinand II of Aragon (Frederick's cousin) had continued the claim of Louis's predecessor, Charles VIII, to the thrones of Naples and Sicily, and in 1501 they deposed Frederick, and Naples initially went to Louis, but by 1504 a new war led to Naples' seizure by Ferdinand of Aragon.
Ferdinand was then taken prisoner by Gonzalo Fernández de Córdoba, and was moved to Barcelona as a hostage.
After Queen Germaine's death on 15 October 1536, Ferdinand married the cultivated widow Mencía de Mendoza in 1541.