Currently, she is chair and professor of English and comparative literature at the American University in Cairo.
As a scholar, Ghazoul has a number of significant publications, notably the encyclopaedic Arab Women Writing: A Critical Reference Guide, 1873-1999 (2008) which she co-edited with Radwa Ashour and Hasna Reda-Mekdashi.
The book was chosen by Choice journal as one of the Outstanding Academic Titles of the year.
Among other works, Ghazoul is the author of Nocturnal Poetics: The Arabian Nights in Comparative Context (AUC Press, 1996).
Ghazoul and co-translator John Verlenden won the award for their translation of Muhammad Afifi Matar's volume of poetry Rubaiyat al-farah (Quartet of Joy).