Fernando Niño de Guevara (1541 – 8 January 1609) was a Spanish cardinal who was also Archbishop of Seville and Grand Inquisitor of Spain.

[1] An uncle, also named Fernando Niño de Guevara (d. 1552), was Archbishop of Granada from 1542 to 1552.

Fernando Niño de Guevara engaged the Jesuits in a dispute about the nature of papal authority.

As a result, Pope Clement VIII prevailed on Philip III of Spain to induce him to resign as Grand Inquisitor in 1602.

In this capacity, he called a synod in 1604 in order to suppress the confraternities and replace them with similar institutions dominated by clerics.