He played professionally in the National Hockey League for his hometown Edmonton Oilers for seven NHL seasons, and one for the Chicago Blackhawks.

Due to the 2004–05 NHL lockout, Pisani went overseas to Europe and played in the Swiss Nationalliga A and Italian Serie A with HC Asiago.

Against the first-seeded Detroit Red Wings, Pisani scored two third period goals (his fourth and fifth of the series) in game six, series-clinching 4-2 victory.

[9] He returned to the Oilers lineup on December 2, 2007, and was nominated that year for the Bill Masterton Trophy, an award given for perseverance and dedication to hockey.

[10][11] The award was subsequently given to Jason Blake of the Toronto Maple Leafs who had been diagnosed with chronic myelogenous leukemia at the start of the season, but still managed to play in all 82 games.

After becoming an unrestricted free agent, Pisani signed a one-year deal with the reigning Stanley Cup champions, the Chicago Blackhawks, for the 2010–11 season, during which he appeared in 60 games and registered 16 points.