He appeared in 144 La Liga matches during nine seasons, scoring a combined 23 goals for Real Madrid, Osasuna and Elche.

He then served a two-year loan at CA Osasuna, making his La Liga debut on 3 September 1961 in a 2–2 home draw against RCD Español[1] and scoring his first goal two weeks later to help the hosts defeat Atlético Madrid 3–1.

[2] Returned to the Santiago Bernabéu Stadium, Serena went on appear in 86 competitive matches (15 goals) and be part of the squads that won four national championships and the 1965–66 edition of the European Cup.

[3][4] After a further two top flight seasons with Elche CF, with whom he took part in the 1969 Copa del Generalísimo Final against Athletic Bilbao,[5] Serena signed with Segunda División club UE Sant Andreu in 1970.

[6] Serena earned one cap for the Spanish national team, playing the second half of the 0–0 friendly home draw to France on 9 January 1963 after coming on as a 46th-minute substitute for Enrique Collar.