Over his 11-year Major League Baseball (MLB) career, Tatís played for the Texas Rangers, St. Louis Cardinals, Montreal Expos, Baltimore Orioles, and New York Mets.

At the age of 17, Tatís was signed as an amateur free agent by Omar Minaya and the Texas Rangers on August 25, 1992.

On April 23, 1999, Tatís hit two grand slams in one inning, against starting pitcher Chan Ho Park of the Los Angeles Dodgers.

[1] After playing only 96 games for the Cardinals in 2000 because of an injury, Tatís was traded to the Montreal Expos along with Britt Reames for Dustin Hermanson and Steve Kline.

The Tampa Bay Devil Rays invited Tatís to spring training in 2004, but he did not make the team and was released.

After being assigned to minor-league baseball camp, Tatís was granted his request to be released from his contract on March 14.

Just nine days later, he signed a minor-league contract with the New York Mets, and spent the 2007 season with its AAA affiliate, the New Orleans Zephyrs.

[7] On May 28, Tatís hit a walk-off double against Justin Miller to defeat the Florida Marlins in the bottom of the 12th inning.

Despite missing the end of the season, on October 23, 2008, Tatís received the Sporting News Comeback Player of the Year Award for the National League.

[15] His younger son Elijah is a middle infielder playing in the Chicago White Sox farm system as of 2022[update].