He joined the main draw as a qualifier, and after defeating Karol Kučera and Max Mirnyi, he lost to countryman Carlos Moyá in the third round.

After this good performance, he had a poor season on clay, and then he lost in the first round at Wimbledon against Finn Jarkko Nieminen in five sets in which he changed tennis racquets to the new Wilson Prestige and took new natural products for increased speed on the court.

He also reached the quarterfinals in Valencia (where he was defending the title), Rome, and New Haven; the semifinals of Saint Petersburg; and was finalist in Kitzbühel, where he lost to Argentine Gastón Gaudio.

Verdasco reached his first Grand Slam fourth round at the U.S. Open, where he lost to Jarkko Nieminen, after defeating Novak Djokovic.

His form improved dramatically for the Rome Masters where he reached the third round, en route he got the better of Carlos Moyá and Nicolás Lapentti (who had beaten him the week earlier) before losing in a thriller to James Blake.

[citation needed] On 23 November, Verdasco won the fourth rubber of Spain's Davis Cup final match against Argentina, defeating José Acasuso.

This was enough to ensure victory for the team; Verdasco had also played in the doubles match the previous day and won, partnering with Feliciano López.

At the third Grand Slam of the year, Wimbledon, he matched his best result at that tournament by reaching the fourth round, where he was ousted by the big-serving Croat, Ivo Karlović.

However, Robin Söderling and Jo-Wilfried Tsonga failed to pass the quarterfinals, allowing Verdasco to qualify for the Tennis Masters Cup for the first time in his career.

To close 2009, Verdasco partnered Feliciano López in the 2009 Davis Cup Final doubles match against the Czech Republic.

Verdasco started his 2010 season at the exhibition tournament AAMI Kooyong Classic in Melbourne, in preparation for the upcoming Australian Open.

He arrived late at the 2010 Regions Morgan Keegan Championships in Memphis, and as a result, he was ousted in the opening round by Jérémy Chardy.

[citation needed] The following week, Verdasco played at the 2010 Barcelona Open, where he defeated Robin Söderling to win his fifth career singles title.

He advanced to the final without losing a set against Rajeev Ram, Ivo Karlović, Denis Istomin and Juan Martín del Potro.

At the Estoril Open Verdasco reached his fifteenth singles final, defeating Frederico Gil, Kevin Anderson and was aided by the retirement of Milos Raonic in the semifinals.

Beginning his grass season at the 2011 Aegon Championships as the 7th seed, he defeated Nicolas Mahut and David Nalbandian in straight sets before losing to Andy Roddick in the quarterfinals.

Verdasco started the year with a first-time participation at the Hopman Cup partnering Anabel Medina Garrigues representing Spain.

The following week Verdasco reached the quarterfinals of the 2013 International German Open, where he was ousted in three tight sets by Argentine qualifier Federico Delbonis.

In November 2013, Verdasco along with doubles partner David Marrero, beat the Bryan brothers to win the Barclays ATP World Tour Finals.

At the 2014 Indian Wells Masters, Verdasco defeated eight-seeded Richard Gasquet to reach quarterfinals, where he lost to John Isner.

The Spaniard won his sixth career singles title at the 2014 U.S. Men's Clay Court Championships by beating Nicolás Almagro in straight sets.

He again reached the fourth round of the 2014 French Open by defeating Richard Gasquet in straight sets, after which he lost to Andy Murray.

Verdasco began the year at the 2015 Qatar ExxonMobil Open defeating Teymuraz Gabashvili in the first round before losing to eventual champion David Ferrer in straight sets.

He reached his 500th career win at the 2018 Mutua Madrid Open making him the sixth Spaniard to join the elite club, and also the ninth active player to achieve the milestone.

[26] Diego Dinomo, who worked with Andrea Hlaváčková and Guillermo García López in the past, and the physio Chema Castillo were also included as part of the new coaching team for 2019.

[30][31] Verdasco struggled with form the rest of the season as he was recovering from a nine-month leg injury[32] and also due to a difficult time post COVID break as he tested positive before the 2020 French Open.

At the 2021 Belgrade Open he recorded two consecutive victories over Frenchmen Lucas Pouille and Adrian Mannarino but lost to eventual finalist, Slovak qualifier Alex Molčan.

In November 2022, Verdasco was banned from professional tennis for two months after testing positive in February for the prohibited drug methylphenidate; he had inadvertently forgotten to renew his Therapeutic Use Exemption for the medication.

Verdasco began playing tennis when he was four years old, practicing with his father on the two hard courts in the backyard of their family home.

[52] Verdasco has often spoken of his love for the English rock band Oasis and once proposed that he would play a tennis match wearing headphones listening to their 1994 album, Definitely Maybe.