[2] The show was hosted by Barth Gimble (Martin Mull) and sidekick announcer Jerry Hubbard (Fred Willard).

Dour bandleader Happy Kyne (Frank De Vol) and the Mirth Makers were the show's stage band, featuring Tommy Tedesco on guitar.

[3] Fernwood 2 Night is set in the fictional small town of Fernwood, Ohio, which is also the setting for Mary Hartman, Mary Hartman, a show in which Mull portrays Barth's twin brother Garth Gimble, who died after being impaled on an aluminum Christmas tree.

[6] In 2001, Mull and Willard reprised their roles in a stage appearance and retrospective at the US Comedy Arts Festival in Aspen, Colorado.

In episode 39, Barth introduces a guest who runs a "nude dude ranch" near Farrington, in Miami County, which places the fictional Fernwood somewhere near Dayton, Ohio.