Box's early career was spent in regional Australia working at stations 2MC/ROXFM Port Macquarie, 3TR Traralgon and 3GG Warragul.

Box is known on television for her "standout" performance on Dancing with the Stars on the Seven Network in 2007 and guest appearances on Sunrise, The Project, Thank God You're Here and Have You Been Paying Attention?

In January 2009, Box joined Sunrise as weather presenter, where she replaced David Brown and stayed in this position until December 2009.

She made her debut on the show on 28 September 2016 and left in late November; her character returned in April 2017.

She attended Tintern Grammar in Ringwood East, and she was appointed school captain in her final year.