Fifth Church of Christ, Scientist is a historic Classical Revival-style Christian Science church building located at 9 East 43rd Street near Madison Avenue and Grand Central Terminal in Manhattan, New York City.

Built in 1921 on the previous site of St. Bartholomew's Episcopal Church, Fifth Church of Christ, Scientist, occupies part of the first two stories of a 21-story office building that was originally named the Canadian Pacific Building.

[6] In 1921, Fifth Church became part of a bonding arrangement for the construction of the 21-story Canadian Pacific Building.

Under it the church received a long-term lease for the space it still occupies.

[7] Fifth Church of Christ, Scientist, is still an active congregation in this location.