The 5th federal electoral district of Mexico City (Distrito electoral federal 05 de la Ciudad de México; previously "of the Federal District") is one of the 300 electoral districts into which Mexico is divided for elections to the federal Chamber of Deputies and one of the 22 currently operational districts in Mexico City.

[1] It elects one deputy to the lower house of Congress for each three-year legislative session by means of the first-past-the-post system.

Votes cast in the district also count towards the calculation of proportional representation ("plurinominal") deputies elected from the fourth region.

[2][3] Under the National Electoral Institute's 2022 districting plan, which is to be used for the 2024, 2027 and 2030 federal elections,[4] the 5th district covers the southern, rural portion of the borough (alcaldía) of Tlalpan down to the border with the state of Morelos, similar to the area covered by the 14th district in the 2005 scheme, together with the northwestern portion of Xochimilco.

[7] Between 1996 and 2005, the district covered the northern portion of the borough of Miguel Hidalgo.