He then joined Brazilian giants Flamengo as a free agent, where he won a number of honours including the Campeonato Brasilero in 2019, 2020, and the Copa Libertadores in 2019, and 2022.

Coming from Figueirense FC as an attacking midfielder,[4] he had his first taste of European football with AFC Ajax in 2004, spending one full season in the Beloften Eredivisie with the reserves.

[5] He was called up for the first team twice by manager Danny Blind for an Eredivisie match against FC Den Bosch and a UEFA Cup game against AJ Auxerre, but remained on the bench for both fixtures.

[6] Despite never playing a competitive match, he credited the Dutch club for helping him learn tactical aspects of the game, as well as aiding his development by allowing him to train with players such as Rafael van der Vaart and Wesley Sneijder.

[8] In August 2005 he was loaned to Real Madrid, spending the entire season with its B team in Segunda División; the move was not made subsequently permanent, after high financial requests from the Uruguayan club.

[14][15] On 23 January 2010, immediately after netting the first in a league game against Athletic Bilbao (an eventual 3–1 home win), Filipe Luís sustained a horrific injury to his right fibula after opposing goalkeeper Gorka Iraizoz landed on his leg – again, he had played all matches and minutes during the campaign, and the side stood fourth in the table.

[16] Amazingly, he returned to action just four months later, appearing in the second half of the 1–0 home victory over RCD Mallorca and being involved in the play which led to Riki's goal;[17] the Galicians would eventually finish in the tenth position.

[21] His official debut came on 26 September at home against Real Zaragoza, where he set up compatriot Diego Costa for the game's only goal, receiving Player of the match accolades.

[25] Filipe Luís made his first appearances in the UEFA Champions League in the 2013–14 edition, helping the Colchoneros secure first place in Group G by scoring once in a 4–0 home rout of FK Austria Wien.

[37] Filipe Luís made his league debut in the third round, featuring the last seven minutes of a 6–3 win at Everton in place of Eden Hazard on 30 August 2014.

[46][47] On 30 January 2016, Filipe Luís was sent off in the first half of a 1–2 loss at FC Barcelona for a challenge on Lionel Messi, and teammate Diego Godín was later also dismissed.

[50] In March 2018, after a collision with FC Lokomotiv Moscow's Eder in a Europa League tie, Filipe Luís broke the fibula in his left leg, initially being thought to miss the rest of the season and thus the 2018 FIFA World Cup[51] but making a recovery in two months.

[57] On 13 June 2024, he was promoted to the under-20 squad, replacing departed Mário Jorge, who left the club to take charge of Saudi Arabia U17 national team.

[69] On 17 November 2015, Filipe Luís scored his first goal for Brazil in a 3–0 defeat of Peru for the 2018 World Cup qualification held in Salvador, Bahia.

[70] In May 2018, he was named in Tite's 23-man squad for the finals in Russia,[71] making his debut in the competition on 27 June when he replaced the injured Marcelo in the early minutes of the 2–0 group stage win against Serbia.