[2] Madonna expressed her gratitude in a statement to Billboard; "dance is my first love [...] so every time one of my songs is celebrated in the clubs and recognized on the charts it feels like home".

She shared photos of her in a recording studio perfecting 50 dance remixes alongside Mike Dean with a little help from Honey Dijon.

The album also features five previously unreleased remixes—"Keep It Together", "American Life", "Nothing Fails", "Turn Up the Radio", and "Living for Love"—by Shep Pettibone, Felix da Housecat, Tracy Young, and Offer Nissim.

[16] Four additional songs were made available on digital platform prior to the release of the album—"Deeper and Deeper" (David's Radio Edit), "Ray of Light" (Sasha Ultra Violet Mix Edit), "Holiday" (7" Version) and "Impressive Instant" (Peter Rauhofer's Universal Radio Mixshow Mix) along with their accompanying music videos on YouTube.

[17][18] On June 23, 2022, Madonna put on a variety show titled WoW, Finally Enough Love as a part of New York City Pride.

[19][20] On August 10, Madonna promoted the album on The Tonight Show Starring Jimmy Fallon and performed "Music" on its "Classroom Instruments" segment.

[21] The same day, Madonna celebrated the album's release with a roller disco party at DiscOasis in Central Park, New York.

[22] AllMusic senior editor Stephen Thomas Erlewine stated that the album "pushes Madonna's artistry to the forefront, as it shows a musician who continually engages with fashions, trends, and innovations.

"[23] Although the 16-track edition "naturally pales in comparison to its parent set", he said that its concentration and mixes still makes it "feel fresh [and] presents a portrait of Madonna as a dance artist, not a pop star.

"[24] Ben Cardew from Pitchfork felt that Madonna's selections for the 16-track edition "offer a curiously distorted look back at her history on the dancefloor," and pointed lesser names of remixers being "over-represented on the second half of the album.

"[27] Sebas E. Alonso from Jenesaispop praised Mike Dean's remastering of Madonna's older songs which makes them "sound so current".

"[9] Bartek Chaciński from Polityka said that the album "explains well the phenomenon of the artist, who, in terms of publishing, took her first steps in the decline of disco, and later her songs accompanied the domination of house on the dance floors or the madness around EDM.

"[28] Sassan Niasseri from Rolling Stone Germany called the album "a pretty confident statement" which demonstrates the change in the demand for variations made especially for the dance floor across four decades.

[32] In a mixed response, George Varga from The San Diego Union-Tribune concluded that "the result on Finally Some Love: 50 Number Ones is an uneven hodgepodge that finds Madonna doing a disservice to her fans and her legacy".

[41][42] It also entered Billboard Japan's Hot Albums chart at number 25, based on combined physical and digital units.

[35] Turkish newspaper Hürriyet named Madonna one of the most important representatives of disco culture in the 1980s, and gave her credit for being part of the rise during the ongoing decade.

[55] Variety ranked album's tracks, with "Into the Groove (You Can Dance Remix Edit)" topping the list, describing the song: "Is arguably the template for the club-pop hybrids that started in the '80s and continue to be released to this very day".