The main museum building, named in honor of art collectors and philanthropists Arnold A. Saltzman and his wife Joan, is a three-story Georgian-style mansion that exemplifies Gold Coast architecture of the late 19th century.

[not verified in body] In addition to the mansion, NCMA, which receives nearly 200,000 visitors each year, includes The Manes Family Art & Education Center, opened in 2017, as well as a Sculpture Park, a Formal Garden, rare specimen trees and marked walking trails.

Encompassing all types of media, the collection includes works by Auguste Rodin, Édouard Vuillard, Pierre Bonnard, Roy Lichtenstein, Larry Rivers, Robert Rauschenberg, Chaim Gross, Moses Soyer, Audrey Flack, Frank Stella, Barbara Prey, George Segal, and Alex Katz among many others.

Among the more than 30 sculptures sited on the property to interact with the natural environment are works by Tom Otterness, Fernando Botero, Chaim Gross, Alejandro Colunga, Masayuki Nagare, Richard Serra, Manolo Valdes Mark DiSuvero, and many others.

In the 1890s, his family sold all but seven acres to former congressman Lloyd Bryce, who hired Ogden Codman, Jr. to build a Georgian Revival mansion on the high ground in the middle of the property, overlooking nearby Hempstead Harbor.