Completed in December 2013,[2] the hospital is the largest building project ever undertaken for the Government of Western Australia.

The opening was delayed by six months to October 2014 due to issues with readiness of new integrated state-of-the-art information technology clinical systems.

[10] The Fiona Stanley facilities incorporate technological innovations such as automated guided vehicles that deliver catering towards, and mobile computer workstations on wheels to assist staff with dispensing of patient medications while accessing required clinical applications.

[12] Phase 1 was the opening of the State Rehabilitation Service, with pathology, pharmacy and medical imaging providing support as required.

[13] It opened on 4 October 2014, with patients from Royal Perth Hospital's Shenton Park campus being transferred to the new facility.

[1] In Phase 2A, several operating theatres and two 24-bed general wards (surgical and medical) opened on 17 November 2014, along with orthopaedic, anaesthetic, hyperbaric medicine and limited intensive care capability.

[16] Another patient suffered a catastrophic aneurysm after a medication to treat low blood pressure was inadvertently given in too high dose.