The James Petigru Boyce Chapel is a historic church building at 1306 Hampton Street in Columbia, South Carolina.

A convention met here on December 17, 1860, whose delegates voted unanimously for South Carolina to secede from the United States, leading to the American Civil War.

It was designated a National Historic Landmark as First Baptist Church, the role it played at the time.

[6] When the Union Army invaded Columbia, they set fire to the Washington Street Methodist Church, South, building, led by the black First Baptist sexton who thought that it was the site of the secession convention.

In 1941 the church was given air conditioning and was extended 35 feet (11 m), with its rear wall moved, giving a place for the choir and a baptistery.

In 1949 fifteen foot side aisles were placed, with steel columns made in Doric style to reinforce and match the old architecture.