Having won his party's nomination for the 2011 presidential election three days earlier, Rosen Plevneliev resigned as Minister of Regional Development and Public Works on September 7.

Minister of Health Stefan Konstantinov, who was being criticized by his own party for failing to deal with the increase in drug prices, resigns.

Konstantinov, defending himself, said that the lack of support from the ruling party was impeding the implementation of reforms that he claims were leading to improved healthcare.

On January 28, 2013, the Prime Minister fired Sergei Ignatov after a review on the Bulgarian National Science fund, carried out by the Inspectorate General of the Council of Ministers, confirmed mounting reports of ministerial mismanagement, including the hiring of unqualified people to the ministry and corruption in the granting process, over the past few months.

The review was triggered by complaints from the Bulgarian Academy of Sciences and Sofia University that the fund was used to funnel millions of levs to unsound projects ignoring the merits of more worthy proposals.