Anchor Angela Miles, reporters Chuck Coppola and Bill Moller, and executive producer Harvey Moshman brought viewers commentary from the floors of the Chicago Mercantile Exchange and the Chicago Board Options Exchange, as well as from their studios in the West Loop.

The program, which typically aired before local and national morning news timeslots, had been marginalized as those shows began to start earlier (as early as 4:00 a.m.), with First Business often moved to lower-rated and lower-viewed graveyard slots.

The production of First Business was later taken over from BizNet by CONUS Communications, a joint venture of Viacom and Hubbard Broadcasting also responsible for All News Channel, who would produce the program until 2003.

Barton Eckert hosted the program from CONUS' bureau in Washington, with his anchor segments being fed via satellite to Hubbard in St. Paul, Minnesota, where news packages acquired from CONUS' local member stations nationwide and other sources would be inserted into the program along with Eckert's anchor segments fed in from Washington, with the finished program being delivered via satellite to local stations from St. Paul very weekday.

With the loss of affiliates for the show as stations began to expand local morning news and force it into a graveyard slot, Weigel decided to shut down the program.