The "official" beginning of the church is recognized as when the first meeting house was constructed the next year.

[4] There is no definitive record of what the first meeting house looked like,[5] but based on the construction of the time, it was likely a simple, small building with a thatched roof.

He used this knowledge to translate the ten commandments, the Lord's prayer, and other scriptures into the Algonquin language, to try converting the natives to Puritan Christianity.

[9] Due to a growth in population in Roxbury,[1][11] as well as the inclusion of residents of Muddy River, who had no place of worship of their own until 1717, in the congregation,[12] a new meeting house was built for the church.

[15] In 1706, residents from "Jamaica End" (the westerly part of Roxbury) asked the general court for permission to be made their own precinct and for help with building their own meeting house, which was denied.

[23][1] As a result of the war, the members of the parish were scattered, and until 1782 there was no official minister for the church.

It is listed as a major structure in the John Eliot Square National Register District, along with the Dillaway-Thomas House.

The church is a two-story wood building with a bell tower, designed in the “Federal Meetinghouse” style.

The tower, which was reconstructed after a hurricane in 1954, contains a bell purchased in 1819 from the Paul Revere Foundry in Canton, Massachusetts that weighs 1538 pounds.

[30] The Unitarian Universalist Urban Ministry is a Roxbury, Boston, MA-based social justice organization focused on providing nonsectarian programs that focus on providing the community with "academic and enrichment programming for children and youth, emergency shelter for individuals and families fleeing from domestic violence, affordable housing and intentional community for young women, including transitional housing for those leaving shelter, and volunteer-based capacity-building services for Roxbury-serving nonprofits.