The 1st federal electoral district of Tlaxcala (Distrito electoral federal 01 de Tlaxcala) is one of the 300 electoral districts into which Mexico is divided for elections to the federal Chamber of Deputies and one of three such districts in the state of Tlaxcala.

It elects one deputy to the lower house of Congress for each three-year legislative session by means of the first-past-the-post system.

Votes cast in the district also count towards the calculation of proportional representation ("plurinominal") deputies elected from the fourth region.

[1][2] The district's head town (cabecera distrital), where results from individual polling stations are gathered together and tallied, is the city of Apizaco.

[3] It comprises the municipalities of Altzayanca, Apizaco, Atlangatepec, Cuapiaxtla, Cuaxomulco, El Carmen Tequexquitla, Emiliano Zapata, Huamantla, Ixtenco, Lázaro Cárdenas, San José Teacalco, Santa Cruz Tlaxcala, Terrenate, Tetla de la Solidaridad, Tlaxco, Tocatlán, Tzompantepec, Xaloztoc and Zitlaltepec de Trinidad Sánchez Santos.