The First Lady's Cup is an annual one-off game, featuring two selected clubs at the end of the season.

[2][3] In early 2021, The Ghana League Clubs Association (GHALCA) began talks with Ghana Football Association (GFA) on the organization of the First Lady's Cup a female version of the President's Cup.

[4] They further set up a four-member committee to work on the competition including Anita Wiredu-Minta, a Ghanaian former international.

[5][6] In May 2021, GHALCA announced that arrangement for the organization of the First Lady's Cup has been concluded and formalized by the association's welfare body.

[7] On 10 December 2021, the maiden edition was played at the Accra Sports Stadium with Hasaacas Ladies emerging victorious after a 4–3 penalty shootout after the match remained goalless after full time.