The First McGillicuddy Block is an historic commercial building at 133 Lisbon Street in Lewiston, Maine.

The block, a fine example of late Victorian architecture, was added to the National Register of Historic Places in 1986.

An orange brick beltcourse lies just below the pressed metal cornice of the roof.

The Ash Street facade is less ornate, but has two oriel window bays, two stories in height, at the second and third floors.

It was built for Daniel J. McGillicuddy, a prominent local lawyer, who had served in the state legislature and as mayor of Lewiston,[2] and later served in the United States Congress.