The Liberal–National coalition ministry was formed following the resignation of the previous Premier, Gladys Berejiklian and the election of Perrottet as leader of the Liberal Party on 5 October 2021.

[2] Paul Toole was elected as National Party leader and subsequently replaced Barilaro as Deputy Premier of New South Wales.

[5] Upon his election as Liberal Party leader, Perrottet announced there would not be a reshuffle until later in the year, with the focus being on bringing New South Wales out of COVID-19 lockdown.

[6] This meant that all ministers would retain their portfolios from the previous Berejiklian ministry except for where there were resignations and/or role changes as a result of the new leadership.

[a][b][c] Perrottet, Ayres, Kean and Brad Hazzard were the first ministers to be sworn in by the Governor Margaret Beazley on 5 October 2021.