In 1925 the Ladies' Foreign Missionary Society already was collecting donations, making it the first such ministry in the world, according to the statistics of the church.

[3] During the Civil War the building was used as a hospital for men wounded, and the churchyard was a detention camp for Union prisoners in the Battle of Chickamauga.

First Presbyterian Church started a missions conference, and the annual event is a combination retreat and workshop for missionaries and their families.

The church was significantly changed in 1847 to incorporate Romanesque round-arched windows and doors and crenellated parapet walls.

A letter signed by President Wilson and some furniture used by his family when they lived in the manse were installed in a classroom.

On February 21, 1997, it was added to the National Register of Historic Places, listed as First Presbyterian Church of Augusta.