First Secretary of State is an office that is sometimes held by a minister of the Crown in the Government of the United Kingdom.

[4] However, when Prime Minister Boris Johnson was moved to an intensive care unit on 6 April 2020, after contracting COVID-19, First Secretary Dominic Raab was asked "to deputise for him where necessary.

"[5] The office temporarily enjoyed some greater constitutional footing between when it was incorporated as a corporation sole in 2002[6] and having all of its remaining functions transferred in 2008.

"[10] Later, Michael Heseltine and John Prescott held the office alongside being Deputy Prime Minister.

[11] The two offices have only existed concurrently with different holders in David Cameron's coalition government, wherein Liberal Democrat Leader Nick Clegg was appointed Deputy Prime Minister while Conservative William Hague was First Secretary.