[10] As of the census[16] of 2000, 4,344 people, 1,785 households, and 1,244 families resided in the county.

About 28.30% of all households were made up of individuals, and 17.80% had someone living alone who was 65 years of age or older.

Fisher County was one of the last rural yellow dog counties in Texas to switch from consistently voting for Democratic candidates to favoring Republican candidates.

From 1921 to 1925, the Democrat Richard M. Chitwood of Sweetwater represented Fisher County in the state House.

He left his post to become the first business manager of Texas Tech University, but died the next year.