Fisk is a small city[4] in Butler County, Southeast Missouri, United States.

It is located right along the Butler-Stoddard County line on U.S. Route 60, along the St. Francis River.

[5] Fisk is included within the Poplar Bluff Micropolitan Statistical Area.

[6] The community was named after Samuel J. Fisk, the proprietor of a local sawmill.

[7] Fisk is located in the flatlands of southeast Missouri on the west bank of the St. Francis River approximately midway between Poplar Bluff and Dexter.

40.5% of all households were made up of individuals, and 17.2% had someone living alone who was 65 years of age or older.

35.5% of all households were made up of individuals, and 18.3% had someone living alone who was 65 years of age or older.

Climate is characterized by relatively high temperatures and evenly distributed precipitation throughout the year.