With a spreading growth habit making it ideal as a shaded garden groundcover, Fittonia can easily be propagated by taking cuttings or by pruning the growing tips.

These fresh clippings will regrow roots simply by placing the cut ends in a vessel of water in a bright, albeit indirectly-lit, location.

Optionally, this method of "water-propagation" may be avoided altogether, as most cuttings may be placed directly into moist substrate, such as sphagnum moss, perlite, coconut (coco) fiber, well-aerated soil, or even LECA (hydroton clay balls).

Notoriously thirsty plants, Fittonia (and Hypoestes) are known to "faint" or wilt when the top layer of substrate begins to dry, but is quickly revived with watering.

This has the added benefit of keeping the leaves free of water droplets or splashed dirt, which could both lead to fungal infections, such as powdery mildew.