[1] He graduated from Liberty High School, where as a senior in 2009, he rushed for 2,229 yards (10.4 per carry) and 28 touchdowns and was named Ohio's co-offensive player of the year in Division III.

In his first appearance for the Wolverines, Toussaint rushed for 129 yards on six carries, including a 61-yard gain in the fourth quarter, against Bowling Green.

[32] He ranked second in the Big Ten Conference in yards per carry behind Wisconsin running back Montee Ball.

[34][35] At the end of the regular season, Michigan offensive coordinator Al Borges praised Toussaint's late season performance (100-plus rushing yards in four of the last five games) and compared him to USC Heisman Trophy winner Charles White: "You put the (USC) jersey on him, you would hardly be able to tell the difference.

"[36] At the time of Michigan's spring practice in April 2012, Borges said there was no running back controversy for the 2012 team: "Fitz is our tailback.

[41] In late August, Toussaint pleaded guilty to operating a vehicle while visibly impaired, after telling the court that he had been drinking brandy before driving.

[45] On November 17, 2012, during a first quarter run in the game against the Iowa Hawkeyes, Toussaint sustained a broken leg, ending his season.

[46] After successful rehabilitation on his leg injury, Toussaint returned as the starting running back for the 2013 Michigan Wolverines football team.

[56] Toussaint was promoted to the Ravens roster on September 6, 2014, after fellow running back Lorenzo Taliaferro was placed on injured reserve.

[60] Throughout his rookie campaign, Toussaint was the Baltimore Ravens' fourth-string running back, behind Justin Forsett, Lorenzo Taliaferro, and Bernard Pierce.

[62] Although he appeared exclusively on special teams, the Ravens defeated the Pittsburgh Steelers 30–17 in the AFC Wild Card Round.

[64][65] He entered training camp competing with Javorius Allen and Terrence Magee to be the Ravens' third running back.

[69] He earned the Steelers' second-string running back position from Jordan Todman as the regular season came to a close.

[70] On January 8, 2016, Toussaint was announced as the starter for Steelers' Wild Card Round playoff game against the Cincinnati Bengals due to an injury to DeAngelo Williams.

[71] In the second round of the playoffs, on January 17, Toussaint scored his first touchdown as a professional but also had a fumble late in the 4th quarter which eventually resulted in the Denver Broncos' game-winning drive.

[75] Toussaint competed with Terrell Watson, Knile Davis, Brandon Brown-Dukes, and Trey Williams to be the third running back on the depth chart.