Fjärdingen's natural border to the north-east is the River Fyris; to the south-east the neighbourhood is limited by Sjukhusvägen and the southern end of the city park, to the south-west by Dag Hammarskjölds väg and Kyrkogårdsgatan and to the north-west by Skolgatan.
Drottninggatan is the main avenue and shopping street in the area, leading southwest from the modern city centre across River Fyris and past Fyristorg uphill to the university library, Carolina Rediviva.
The final climb uphill through the park landscape to the library is commonly referred to as Carolinabacken, the site of yearly student festivities during the traditional Valborg celebrations on April 30.
Sysslomansgatan/Västra Ågatan are the main north-south business streets, running parallel to the river past Fyristorg and joining at Sankt Olofsgatan.
The space, shaped like a church, includes the large metal art installation Befrielsen (Liberation), by local artist Olof Hellström, depicting Martin Luther King Jr.'s efforts (plan) to pull apart the bars restricting civil rights.
A short cobbled street, Valvgatan, connects the Dombron bridge and Fyristorg with Riddartorget, the open place in front of the stairs leading up to the southern cathedral entrance.
The writer and poet Karin Boye lived in Fjärdingen during her undergraduate studies in Uppsala and wrote several works partially inspired by her own student experience.
Gösta Knutsson's (1908–1973) children's book series about the cat Pelle No-Tail are mainly set in Fjärdingen, as are some of crime writer Kjell Eriksson's Ann Lindell novels.
Ingmar Bergman spent part of his childhood at his grandmother's apartment in Trädgårdsgatan and watched his first silent films in the Slottsbiografen cinema, which has been restored to its early 20th century state and today is used for events.
His semi-autobiographical work Fanny and Alexander was also partially shot in Fjärdingen, with the University Mill doubling as the home of the severe bishop.