Saretta has won one ATP Tour doubles title, the 2004 Croatia Open Umag with José Acasuso, defeating Czech players Jaroslav Levinský and David Škoch in the final.

He reached his highest singles ATP-ranking on September 15, 2003, when he became the number 44 of the world, capping what would be the best season of his professional career.

His clay court prowess was also evident when he was successful in defending his crown at the Bermuda Challenger tournament in April.

Flávio Saretta won the Rio Pan-American Games 2007, after saving 2 match-points at semi and at final against, respectively, Eduardo Schwank and Adrián García.

In 2009, Saretta announced that he will stop playing professionally because he is tired of "fighting against the pain" of his injuries.