The UIC Flames are the intercollegiate athletic teams that represent the University of Illinois Chicago, located in Chicago, Illinois, in intercollegiate sports as a member of the Division I level of the National Collegiate Athletic Association (NCAA), primarily competing in the Missouri Valley Conference (MVC) since the 2022–23 academic year.

In 1946, the Chicago Illini represented the two-year University of Illinois undergraduate division located on Navy Pier.

[9][10] UIC announced on January 26, 2022, that it would join the Missouri Valley Conference (MVC) as its 12th member institution effective July 1 that same year.

[11] The Horizon League initially banned UIC student-athletes from its conference tournaments for the remainder of the year, but reversed its decision eleven days later.

[13][14][15] UIC competes in 18 intercollegiate varsity sports:[16] men's sports include baseball, basketball, cross country, soccer, swimming & diving, tennis and track & field (indoor and outdoor); women's sports include basketball, cross country, golf, soccer, softball, swimming & diving, tennis, track & field (indoor and outdoor) and volleyball.

The men's basketball team has earned six postseason appearances: three NCAA Tournaments (1998, 2002, 2004), one NIT (2003), one CBI (2017), and one CIT (2018).

Jimmy Collins was head coach from 1996-2010 and led the Flames to four postseason appearances (three NCAAs and one NIT) and a 218-208 overall record.

[17] He was replaced by Indiana assistant and former Wyoming head coach Steve McClain[18] who compiled a 79-93 record in five seasons.

Missouri Tigers assistant and Oak Park, IL native Ashleen Bracey was hired as head coach in March 2022.

UIC Baseball has made six NCAA Regional Appearances and won 12 regular season conference championships.

[26][27] A three-time MLB All Star, four-time MLBPA Marvin Miller Man of the Year recipient (2009, 2016, 2018, 2019), and Roberto Clemente Award winner (2016), Granderson's $5 million gift to help build UIC's Granderson Baseball Stadium is among the largest known one-time donations by a professional athlete to his or her alma mater, according to Sports Illustrated.

[29] The Flames women's tennis program has been dominant for the past two decades, winning 19 conference championships and making 17 NCAA Tournament appearances.