Flatbush Zombies have collaborated with various artists, including RZA, ASAP Mob, Z-Breezy, Jim Jones, Juicy J, Danny Brown, Action Bronson, Mr. Muthafuckin eXquire, Tech N9ne, and Anthony Flammia among others.

The group grew in popularity through two mixtapes and several music videos, leading to their 2016 debut studio album, 3001: A Laced Odyssey.

Friends since grade school, all three members were born and raised in the Flatbush section of Brooklyn, New York City.

Demetri Simms (Meechy Darko), Antonio Lewis (Zombie Juice) and Erick Elliott (The Architect) first bonded over the Japanese anime Dragon Ball Z and Professional Wrestling.

Zombie Juice, along with fellow Flatbush native Issa Gold of the Underachievers (Erick did not participate), specifically started looking into the indigo lifestyle.

Meechy Darko said the first time he took psilocybin mushrooms, he underwent Ego death and had a sort of rebirth of consciousness.

[5][6] Later in the year, Flatbush Zombies released their debut mixtape, titled D.R.U.G.S., which stands for "Death and Reincarnation Under God's Supervision."

"[12][13] In September 2014, it was announced that Flatbush Zombies would be touring with fellow Brooklyn-based rap group the Underachievers, and they would be collectively known as Clockwork Indigo.

On March 15, 2015, Flatbush Zombies released a new single on SoundCloud titled "Red Eye to Paris" featuring UK Grime artist Skepta.

On September 11, 2015, at 9:11 pm EST, the group released a new single and socially charged music video on YouTube titled "Blacktivist".