[5][6] S. depressus is an endemic with a restricted range, historically inhabiting the Black Warrior River drainage of north central Alabama.

[7] Both the common name and specific name refer to the fact that the species' carapace (upper shell) is much lower and flatter than those of the other members of the genus Sternotherus.

The ideal habitat for the flattened musk turtle is a clearwater stream or river that has an adequate amount of cover sites to escape to under rocks and crevices.

In absence of quality cover in rocks and crevices, the flattened musk turtle will dig under logs or brush.

[citation needed] Although reproductive rates are low for the species, S. depressus has been bred infrequently in captivity with relative success.

Strip mining for coal has increased the amount of silt and particulates in the waters of the Warrior River drainage system.