Flavius Domide started playing football as a child on the streets of the Pârneava neighborhood of Arad where he was born and raised.

[4] He later went to play for the juniors of UTA Arad, a team where he would spend most of his senior career, having a total of 342 Divizia A appearances for the club in which he scored 75 goals, a competition in which he made his debut on 28 August 1966 in a 0–0 against Rapid București, also he appeared in 16 matches in which he scored 6 goals in European competitions.

[4][9] Flavius Domide played 17 matches and scored 3 goals for Romania (19/3 including Romania's Olympic team games), making his debut on 6 November 1968 when coach Angelo Niculescu sent him on the field in the 77th minute in order to replace Nicolae Dobrin in a friendly which ended 0–0 against England.

[1][10] His following game was at the successful 1970 World Cup qualifiers in a 2–0 victory against Switzerland in which he scored a goal, also he was selected by Angelo Niculescu to be part of Romania's squad at the final tournament where he didn't play.

[1][3][4] He played 5 matches at the 1972 Euro qualifiers, managing to reach the quarter-finals where Romania was defeated by Hungary, who advanced to the final tournament.