[2] When released on August 20, 1937, Flight from Glory was considered one of the films that broke new ground in "pioneering airline sagas", comparing favorably to big-budget features such as 1936's Thirteen Hours by Air.

[3][4]Ellis (Onslow Stevens) runs Trans-Andean Air Service, a run-down company transporting supplies from Delgado, a tiny, remote outpost, over the Andes Mountains to some mines.

"Mousey" Mousialovitch (Solly Ward), the chief mechanic and former pilot, takes over the operation, with the mine owners promising new aircraft will be delivered.

Flight from Glory was directed by B-movie specialist Lew Landers, who would eventually helm nine aviation films for RKO Radio Pictures.

Flight from Glory was also one of the early films that featured Van Heflin, who was being groomed for stardom by appearing in low-budget B-features.