It is served by Amtrak's Blue Water route, and doubles as the intercity bus station for Amtrak Thruway and Indian Trails, as well as the local city bus service, the Flint Mass Transportation Authority, who owns the station.

The railroad line that now hosts the Blue Water arrived from Port Huron in 1871 and originally a wooden structure served as the passenger station.

[citation needed] A permanent stone and brick station replaced it in 1905, but was moved to Muskegon in 1927.

[2] The third GTW depot, located at 120 East 14th Street near Downtown Flint, was used by Amtrak until 1989 and demolished thereafter.

From 1982–2004, the station was served by the International Limited, which was operated jointly by Via Rail and Amtrak and ran between Chicago and Toronto.