In 1957, she began recording for Musart Records and became one of the label's exclusive artists with numerous best-selling singles, such as "Cielo rojo", "Renunciación", "Gracias", "Cariño santo", "Mi destino fue quererte", "Mi casita de paja", "Toda una vida", "Amar y vivir", "Gaviota traidora", "El mar y la esperanza", "Celosa", "Vámonos", "Cachito de mi vida", "Miel amarga", "Perdámonos", "Tres días", "No vuelvo a amar", "Las noches las hago días", "Estrellita marinera", and "La basurita", among others.

Director Ismael Rodríguez gave her important roles in La cucaracha (1959), and Ánimas Trujano (1962), which was nominated for an Academy Award for Best Foreign Language Film.

[12] She loved the mariachi music of famous Mexican singers Jorge Negrete and Lucha Reyes,[12] and also sang songs that belonged to the pasodoble, tango, and bolero genres, which were popular in Mexico in the late 1930s.

[14] Her mother, who wanted to live in Mexico City, urged her father to sell all their property in Salmanca and relocate the family to the Mexican capital.

[12] María de Jesús took her three youngest children with her to Mexico City, leaving the oldest four (including Guillermina) in Salamanca in the care of her sisters, who were nuns.

She and her father attended a performance of the famous Mariachi Pulido at the Teatro del Pueblo, a theater located in the Abelardo L. Rodríguez Market in central Mexico City.

[15] Arturo Blancas, an Excélsior journalist and XEFO announcer, thought she looked more "like a flower" than a soldier and suggested she change her stage name to La Amapola, which means "the poppy".

[15] Blancas then chose the title of Dolores del Río's 1943 drama film as the young singer's new stage name, and Guillermina Jiménez became Flor Silvestre, which means "wild flower".

[15] Her participation in the contest earned her a contract to sing in revues at the Teatro Colonial, located on San Juan de Letrán Avenue (now Eje Central).

[15][12] The Teatro Colonial was "Mexico's most popular [theater]" in the 1940s,[18] and Flor Silvestre's performances there were noticed by a showman who hired her as part of his touring company.

[12] Flor Silvestre's family was experiencing financial problems at the time, and she sang at banquets and other places in order to win more money and help her parents.

The Guadalajara newspaper El Informador described her as "Flor Silvestre, young XEW singer, who represents the feeling of our land within the ranchera song".

Journalist Mónica Fio wrote in her column "Micrófono": We unreservedly commend the young singer "Flor Silvestre" because her radio career, though rapid, is made on the basis of effort, perseverance, and study.

"Imposible olvidarte", "Que Dios te perdone", "Pobre corazón", "Viejo nopal", "Guadalajara", and "Mi amigo el viento" were recorded with Gilberto Parra's mariachi.

[28] She was reunited with her Primero soy mexicano co-stars Luis Aguilar and Francisco Avitia in the film El tigre enmascarado, which premiered in 1951.

[30] An adaptation of Rómulo Gallegos' novel Sobre la misma tierra, the film features Flor Silvestre in the role of Cantaralia Barroso, the mother of the novel's protagonist, Remota Montiel (played by Elsa Aguirre).

Flor Silvestre had one of the starring roles in the stage play La hacienda de Carrillo, a revue which opened on 1 July 1955 at the new Teatro Ideal.

[31] Written by Carlos M. Ortega and Pablo Prida, the play was about "a hacienda in the interior [of the country], whose owner leaves his land to embrace politics, become a deputy, and come to the metropolis in the company of his daughters".

2, which includes her hits "Gracias", "Perdí la partida", "Bendición de Dios", "Árboles viejos", "Te digo adiós", "Un jarrito", "Quédate esta vez", and "Plegaria".

[36] "Mi destino fue quererte" peaked at number 4 on Record World Latin American Single Hit Parade[37] and became one of Flor Silvestre's signature songs.

[39] The album also includes her hits "Gaviota traidora", "El mar y la esperanza", "Amor se escribe con llanto", and "Espumas".

The album features cover versions of popular boleros from the 1950s, including "Un siglo de ausencia", "Condición", "El reloj", and "La barca".

Billboard included Canciones con alma in its Top Album Picks section and wrote, "A good solid LP overall of love ballads.

She also played Felipe Carrillo Puerto's wife, Isabel Palma, in the film Peregrina (released in 1974), in which she sang the Guty Cárdenas bolero "Quisiera".

The album's release coincided with her appearance in the film Mi aventura en Puerto Rico, in which she sang "Desvelo de amor" and "Obsesión".

In 2001, she released her second banda album, Flor Silvestre con tambora, which includes new versions of her 1960s hits "Cariño santo", "Celosa", "Desolación", "Mi destino fue quererte", and "El mar y la esperanza".

On 9 March 2015, her documentary Flor Silvestre: su destino fue querer premiered at Zapopan's Plaza de las Américas as part of the Guadalajara International Film Festival.

[55][56] The 24-minute documentary features interviews with Flor Silvestre, who recounts her life and career; her five children, Dalia, Francisco, Marcela, Antonio, and Pepe; and singers Angélica María and Guadalupe Pineda.

[59] In 1953, Flor Silvestre married radio announcer and bullfighting chronicler Francisco Rubiales Calvo "Paco Malgesto" (1914–1978), who would become an Icon of Mexican television.

They first met in 1950 and had a on going relationship behind her husband back for years, starting when he was invited to sing on her program Increíble pero cierto at the Verde y Oro studio of radio station XEW in Mexico City.